Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10307430 | Schizophrenia Research | 2014 | 8 Pages |
Abstract
This study presents a mechanism by which 25(OH)D insufficiency confers risk of schizophrenia; via proline elevation due to reduced PRODH expression, and a concomitant dysregulation of neurotransmission. Although definitive causality cannot be confirmed, these findings strongly support vitamin D supplementation in patients, particularly for those with elevated proline, who may represent a large subgroup of the schizophrenia population.
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Authors
James D. Clelland, Laura L. Read, Valérie Drouet, Angela Kaon, Alexandra Kelly, Karen E. Duff, Robert H. Nadrich, Amit Rajparia, Catherine L. Clelland,