Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10307791 | Schizophrenia Research | 2014 | 7 Pages |
Abstract
Alterations in DTI metrics suggest white matter microstructural anomalies of the ALIC, fornix, and UF in 22q11.2DS. Structural differences in ALIC appear to be associated with the Nogo-66 receptor gene, which has been linked to myelin-mediated axonal growth inhibition. Moreover, the association between psychosis symptoms and ALIC and UF metrics suggests that the Nogo-66 receptor gene may represent a susceptibility gene for psychosis through its disruption of white matter microstructure and myelin-associated axonal growth.
Keywords
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Matthew D. Perlstein, Moeed R. Chohan, Ioana L. Coman, Kevin M. Antshel, Wanda P. Fremont, Matthew H. Gnirke, Zora Kikinis, Frank A. Middleton, Petya D. Radoeva, Martha E. Shenton, Wendy R. Kates,