| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10313 | Biomaterials | 2007 | 9 Pages |
Abstract
Postoperative peritoneal adhesions cause pelvic pain, infertility, and potentially lethal bowel obstruction. We have designed and synthesized an injectable hydrogel composed of cross-linkable modified hyaluronic acids (HAs) conjugated to dexamethasone (HAX-DEX), and investigated its anti-inflammatory function. HAX-DEX formed a hydrogel in <1 min by cross-linking reactions between aldehyde groups and hydrazide groups. The hydrogel degraded in media over 5 days, releasing dexamethasone slowly over that time, reducing TNF-α and IL-6 production from lipopolysaccharide-stimulated primary mouse macrophages in vitro. HAX-DEX was biocompatible on subcutaneous injection, and caused less inflammation than unmodified cross-linked HA.
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Authors
Taichi Ito, Iain P. Fraser, Yoon Yeo, Christopher B. Highley, Evangelia Bellas, Daniel S. Kohane,