Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10320519 | Artificial Intelligence in Medicine | 2013 | 11 Pages |
Abstract
Current studies use structure learning algorithms in conjunction with ad hoc thresholds for identifying significant associations in graphical abstractions of biological pathways and signalling mechanisms. Such an ad hoc choice can have pronounced effect on attributing biological significance to the associations in the resulting network and possible downstream analysis. The statistically motivated approach presented in this study has been shown to outperform ad hoc thresholds and is expected to alleviate spurious conclusions of significant associations in such graphical abstractions.
Related Topics
Physical Sciences and Engineering
Computer Science
Artificial Intelligence
Authors
Marco Scutari, Radhakrishnan Nagarajan,