Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10333036 | Journal of Computer and System Sciences | 2005 | 21 Pages |
Abstract
One of the most promising ways to determine evolutionary distance between two organisms is to compare the order of appearance of orthologous genes in their genomes. The resulting genome rearrangement problem calls for finding a shortest sequence of rearrangement operations that sorts one genome into the other. In this paper we provide a 1.5-approximation algorithm for the problem of sorting by transpositions and transreversals, improving on a five-year-old 1.75 ratio for this problem. Our algorithm is also faster than current approaches and requires O(n3/2logn) time for n genes.
Related Topics
Physical Sciences and Engineering
Computer Science
Computational Theory and Mathematics
Authors
Tzvika Hartman, Roded Sharan,