Contribution of canonical feed-forward loop motifs on the fault-tolerance and information transport efficiency of transcriptional regulatory networks

Specifically, we observed that canonical feed forward loops demonstrate a strong negative correlation with the average shortest path, diameter and closeness centralities while they show a strong positive correlation with the average local clustering coefficient. Moreover, we observed that such motifs seem to be evenly distributed in the transcriptional regulatory network; however, the direct edges of multiple such motifs seem to be stitched together to facilitate shortest path based routing in such networks.