| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10345572 | Computer Methods and Programs in Biomedicine | 2013 | 8 Pages |
Abstract
This paper presents the R package pocrm for implementing and simulating the partial order continual reassessment method (PO-CRM; [1], [2]) in Phase I trials of combinations of agents. The aim of this article is to illustrate, through examples of the pocrm package, how the PO-CRM works and how its operating characteristics can inform clinical trial investigators. This should promote the use of the PO-CRM in designing and conducting dose-finding Phase I trials of combinations of agents.
Related Topics
Physical Sciences and Engineering
Computer Science
Computer Science (General)
Authors
Nolan A. Wages, Nikole Varhegyi,