Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10356114 | Journal of Biomedical Informatics | 2011 | 8 Pages |
Abstract
Although it is possible to perform enrichment analysis using ontologies other than the GO, a key pre-requisite is the availability of a background set of annotations to enable the enrichment calculation. In the case of the GO, this background set is provided by the Gene Ontology Annotations. In the current work, we describe: (i) a general method that uses hand-curated GO annotations as a starting point for creating background datasets for enrichment analysis using other ontologies; and (ii) a gene-disease background annotation set - that enables disease-based enrichment - to demonstrate feasibility of our method.
Keywords
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Physical Sciences and Engineering
Computer Science
Computer Science Applications
Authors
Paea LePendu, Mark A. Musen, Nigam H. Shah,