Integrating clinical research with the Healthcare Enterprise: From the RE-USE project to the EHR4CR platform

The RE-USE approach used mapping algorithms to identify semantic coherence between clinical care and clinical research data elements and pre-populate eCRFs. The RE-USE project utilized SNOMED International v.3.5 as its “pivot reference terminology” to support EHR-to-eCRF mapping, a decision that likely enhanced the “recall” of the mapping algorithms. The RE-USE results demonstrate the difficult challenges involved in semantic integration between the clinical care and clinical research contexts.