| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10376503 | Journal of Colloid and Interface Science | 2012 | 8 Pages |
Abstract
⺠We designed a new synthetic peptide (NLS) to act as a nuclear localization signal. ⺠The peptide was included in DNAhsp65/cationic liposome as a gene vaccine. ⺠The peptide/DNAhsp65 complex was inserted into the liposome structure. ⺠Peptide inclusion presented in vivo therapeutic effects against tuberculosis. ⺠The pseudo-ternary complex is a promising gene vaccine for tuberculosis treatment.
Keywords
LPSDOTAPEPCNLSERK1,2-dioleoyl-sn-glycero-3-phosphoethanolamine1,2-dioleoyl-3-trimethylammonium-propaneMTTinterleukinTuberculosisDNA deliverynuclear localization signalnuclear localization signalsInfectious diseaseCationic liposomelipopolysaccharideGene vaccineDOPEextracellular signal-regulated kinases
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Rogério Silva Rosada, Célio Lopes Silva, Maria Helena Andrade Santana, Clóvis Ryuichi Nakaie, Lucimara Gaziola de la Torre,