| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10376842 | Journal of Colloid and Interface Science | 2011 | 7 Pages |
Abstract
⺠Particle interactions in pMDI combination products (Symbicort and Seretide) were studied by AFM and Raman microscopy. ⺠Drug components in Symbicort (budesonide and formoterol) deposit on ACI plates as individual particles. ⺠Salmeterol and fluticasone tend to form aggregates. ⺠This tendency is evidenced with AFM measurements, and suggest a chemical synergy between salmeterol and fluticasone not present between formoterol and budesonide.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Philippe G.A. Rogueda, Robert Price, Tim Smith, Paul M. Young, Daniela Traini,