pH-responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: Synthesis, in vitro and in vivo evaluation

► Novel pH-responsive IPN hydrogel beads were synthesized for drug delivery application. ► IPN hydrogel beads offered pulsatile swelling and drug release behavior in response to pH. ► A maximum drug release of 10% in pH 1.2 solution and 90% in pH 7.4 was recorded. ► Stomach histopathology of albino rats suggested the usefulness of IPN hydrogel beads.