| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10376911 | Journal of Colloid and Interface Science | 2012 | 9 Pages |
Abstract
⺠Amorphous nanoparticle complex (nanoplex) of sparingly soluble drug. ⺠Prepared by sustainable self-assembly drug-polyelectrolyte complexation process. ⺠Spherical nanoplex with 80% drug loading, >80% complexation efficiency and yield. ⺠Twice higher dissolution rate and solubility, stable in storage. ⺠Promising bioavailability-enhanced formulation of poorly soluble drugs.
Keywords
PEITGAPVPPXRDCIPAPICTABSDSATCCPBSHPMCDXTDSCMHbAmorphousSolubilitycomplexation efficiencyThermogravimetric analysisSelf-assemblysodium dodecyl sulfateDextran sulfateCiprofloxacinphosphate buffer salineAmerican Type Culture CollectionActive pharmaceutical ingredientsMueller Hinton BrothField emission scanning electron microscopyNanoparticleHydroxypropylmethylcellulosePowder X-Ray Diffractionpolyethyleneiminepolyvinylpyrrolidoneoptical densityDifferential scanning calorimetry
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Wean Sin Cheow, Kunn Hadinoto,