| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10410284 | Sensors and Actuators B: Chemical | 2011 | 10 Pages |
Abstract
A microfluidic platform for precise biochemical control of the extracellular microenvironment was developed. A chemical interface was established with cells or tissues through the precise and focal delivery of soluble chemical agents through a pore addressed by a polymer microchannel. Thermal flow sensors were integrated along the length of the microchannel and monitored internal flow rate. Sensor performance was characterized in anticipation of future studies with real-time feedback control of focal delivery. The microfluidic system was characterized by determining the fluid delivery rates through the pores and concentration profiles of agents delivered. Finally, focal delivery to rat retinal tissue was demonstrated.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jonathan T.W. Kuo, Li-Yuan Chang, Po-Ying Li, Tuan Hoang, Ellis Meng,