Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10411143 | Sensors and Actuators B: Chemical | 2005 | 6 Pages |
Abstract
4-Amino-2-mercaptopyrimidine self-assembled monolayers (AMP/Au SAMs) have been fabricated on bare gold. The ethamsylate can adsorb onto the AMP/Au SAMs electrode surface to form a closely packed monolayer, whose surface concentration is 2.5Ã10â10 mol cmâ2. The modified electrode was applied successfully to the determination of ethamsylate in the presence of dopamine, norepinephrine and epinephrine without prior separation, and could eliminate their interference at 40-, 70- and 110-fold concentration of 6.0Ã10â6 mol lâ1 ethamsylate, respectively. The modified electrode provides a linear response for ethamsylate in the concentration range from 4.0Ã10â7 to 1.0Ã10â3 mol lâ1 by square wave adsorptive stripping voltammetry. The detection limit (three times the signal blank/slope) was 6.0Ã10â8 mol lâ1. The recovery experiment of standard addition in drug samples of ethamsylate showed the recoveries in the range of 98.7-103.1%. The modified electrode has been satisfactorily used for the determination of ethamsylate in pharmaceutical formulations.
Related Topics
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Authors
Xiu-Hua Zhang, Sheng-Fu Wang,