Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10441464 | Personality and Individual Differences | 2005 | 7 Pages |
Abstract
We examined the relationship between type 4 dopamine receptor gene and cigarette-smoking behavior and the mediating role of the temperamental dimension novelty seeking (NS). Participants were 150 smoking and non-smoking high and low NS scorers from a randomized population-based sample of 20-35 year old men and women. We genotyped the participants for a 48 base-pair repeat polymorphism in the DRD4 gene. Novelty seeking was assessed by the Temperament and Character Inventory. The two- and five-repeat alleles were significantly more common in the group of current smokers than others (odds ratio 2.53, 95% CI 1.06-6.01). After controlling for the effect of novelty seeking on smoking behavior, the relationship dropped substantially, being no longer statistically significant.
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Authors
Marko Elovainio, Mika Kivimäki, Jorma Viikari, Jesper Ekelund, Liisa Keltikangas-Järvinen,