A simulation study of sample size demonstrated the importance of the number of events per variable to develop prediction models in clustered data

Article ID	Journal	Published Year	Pages	File Type
10513474	Journal of Clinical Epidemiology	2015	9 Pages	PDF

Abstract

We recommend at least 10 EPV to fit prediction models in clustered data using logistic regression. Up to 50 EPV may be needed when variable selection is performed.

Keywords

Clustered data Events per variable Logistic model Prediction model Simulation study Multicenter study

Related Topics

Health Sciences Medicine and Dentistry Public Health and Health Policy

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A simulation study of sample size demonstrated the importance of the number of events per variable to develop prediction models in clustered data

Authors

L. Wynants, W. Bouwmeester, K.G.M. Moons, M. Moerbeek, D. Timmerman, S. Van Huffel, B. Van Calster, Y. Vergouwe,