Head-to-head randomized trials are mostly industry sponsored and almost always favor the industry sponsor

Article ID	Journal	Published Year	Pages	File Type
10513820	Journal of Clinical Epidemiology	2015	10 Pages	PDF

Abstract

The literature of head-to-head RCTs is dominated by the industry. Industry-sponsored comparative assessments systematically yield favorable results for the sponsors, even more so when noninferiority designs are involved.

Keywords

Industry sponsorship noninferiority trials Head-to-head comparison Randomized controlled trials Conflict of interest Cross-sectional study

Related Topics

Health Sciences Medicine and Dentistry Public Health and Health Policy

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Head-to-head randomized trials are mostly industry sponsored and almost always favor the industry sponsor

Authors

Maria Elena Flacco, Lamberto Manzoli, Stefania Boccia, Lorenzo Capasso, Katina Aleksovska, Annalisa Rosso, Giacomo Scaioli, Corrado De Vito, Roberta Siliquini, Paolo Villari, John P.A. Ioannidis,