Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10513963 | Journal of Clinical Epidemiology | 2012 | 6 Pages |
Abstract
Apparently, robust treatment effects on surrogates are likely to lead to small and uncertain effects on patient-important outcomes. We should be cautious in advising patients to adopt a therapy when compelling evidence is restricted to its impact on surrogate outcomes, particularly if that therapy may be toxic or otherwise cause harms.
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Authors
Stephen D. Walter, Xin Sun, Diane Heels-Ansdell, Gordon Guyatt,