Article ID Journal Published Year Pages File Type
10513963 Journal of Clinical Epidemiology 2012 6 Pages PDF
Abstract
Apparently, robust treatment effects on surrogates are likely to lead to small and uncertain effects on patient-important outcomes. We should be cautious in advising patients to adopt a therapy when compelling evidence is restricted to its impact on surrogate outcomes, particularly if that therapy may be toxic or otherwise cause harms.
Related Topics
Health Sciences Medicine and Dentistry Public Health and Health Policy
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