| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10529270 | Analytica Chimica Acta | 2005 | 7 Pages |
Abstract
The proposed HPLC method was applied to the urine of normal and diabetic rats induced by intraperitoneal administration of streptozotocin, and significant increases in d-lactate excreted into the urine were observed in diabetic rats compared to normal rats. In diabetic rats, d-lactate concentrations showed a rising tendency from the seventh day and then remained stable from the 28th day after induction, suggesting that urinary d-lactate may be used as an indicator to determine the diabetic stage and the level of kidney damage.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jen-Ai Lee, Yih-Chiao Tsai, Hsiang-Yin Chen, Chih-Chun Wang, Shih-Ming Chen, Takeshi Fukushima, Kazuhiro Imai,