| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10567329 | Bioelectrochemistry | 2005 | 9 Pages |
Abstract
Automated chemical synthesis of selected probes was performed and the oligonucleotides produced were covalently conjugated to the sensing surface of a quartz microbalance. The microgravimetric sensor was tested in a flow chamber by measuring the variation of resonance frequency due to the binding of synthetic target substrates. Specific dose dependent binding was observed. Furthermore, the binding of a transcribed full-length mRNA substrate was successfully monitored under similar conditions.
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Physical Sciences and Engineering
Chemistry
Electrochemistry
Authors
L. Tedeschi, A. Mercatanti, C. Domenici, L. Citti,