| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10702 | Biomaterials | 2006 | 5 Pages |
Abstract
In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Patrick H. Warnke, Jörg Wiltfang, Ingo Springer, Yahya Acil, Hendrik Bolte, Markus Kosmahl, Paul A.J. Russo, Eugene Sherry, Ulf Lützen, Stefan Wolfart, Hendrik Terheyden,