Analysis of three leakage-correction methods for DSC-based measurement of relative cerebral blood volume with respect to heterogeneity in human gliomas

The impact of leakage is complex, thus adequate correction necessitates care. Standardized input parameters are one important factor for comparability of rCBV and K2 values among patients. The extension of DSC analysis with K2 maps could potentially allow improved differentiation between tumor grades. Further methods need to integrate special advantages of existing approaches to achieve more reliable rCBV estimates within clinically reasonable calculation times.