Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10712797 | Magnetic Resonance Imaging | 2011 | 8 Pages |
Abstract
This study analyzed the change in breast density in women receiving tamoxifen treatment using 3-D MRI. Sixteen women were studied. Each woman received breast MRI before and after tamoxifen. The breast and the fibroglandular tissue were segmented using a computer-assisted algorithm, based on T1-weighted images. The fibroglandular tissue volume (FV) and breast volume (BV) were measured and the ratio was calculated as the percent breast density (%BD). The changes in breast volume (ÎBV), fibroglandular tissue volume (ÎFV) and percent density (Î%BD) between two MRI studies were analyzed and correlated with treatment duration and baseline breast density. The ÎFV showed a reduction in all 16 women. The Î%BD showed a mean reduction of 5.8%. The reduction of FV was significantly correlated with baseline FV (P<.001) and treatment duration (P=.03). The percentage change in FV was correlated with duration (P=.049). The reduction in %BD was positively correlated with baseline %BD (P=.02). Women with higher baseline %BD showed more reduction of %BD. Three-dimensional MRI may be useful for the measurement of the small changes of ÎFV and Î%BD after tamoxifen. These changes can potentially be used to correlate with the future reduction of cancer risk.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Condensed Matter Physics
Authors
Jeon-Hor Chen, Yeun-Chung Chang, Daniel Chang, Yi-Ting Wang, Ke Nie, Ruey-Feng Chang, Orhan Nalcioglu, Chiun-Sheng Huang, Min-Ying Su,