Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10731892 | Radiation Physics and Chemistry | 2005 | 6 Pages |
Abstract
The drug uptake and release of anticancer drug from N-isopropylacrylamide/itaconic acid copolymeric hydrogels containing 0-3Â mol% of itaconic acid irradiated at 48Â kGy have been investigated. 5-Fluorouracil (5-FU) is used as a model anticancer drug. The effect of 5-FU solution on swelling characteristics of PNIPAAm and P(NIPAAm/IA) copolymeric hydrogels have also been studied. The percent swelling, equilibrium swelling, equilibrium water/5-FU content and diffusion constant values are evaluated for poly(N-isopropylacrylamide) (PNIPAAm) and poly(N-isopropylacrylamide/itaconic) (P(NIPAAm/IA)) hydrogels at 130Â ppm of 5-FU solution at room temperature. Diffusion of 5-FU solution into the hydrogels has been found to be the non-Fickian type. Finally, the kinetics of drug release from the hydrogels are examined.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
B. TaÅdelen, N. Kayaman-Apohan, O. Güven, B.M. Baysal,