Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents

Article ID	Journal	Published Year	Pages	File Type
10736872	Experimental Gerontology	2013	7 Pages	PDF

Abstract

âº MR extends lifespan. âº Lifespan extension by MR is associated with decreased adiposity and improvement of insulin sensitivity. âº Decreased adiposity is a response to metabolic adaptations in adipose tissue. âº Insulin sensitivity is associated with lipid metabolic changes in liver. âº MR mediated effects are reversed by cysteine supplementation of the MR diet.

Keywords

AHCY IGF-1 CBS 8-oxo-dG CTh FRL SAH CCL7 F344 GCLM BHMT sirtuin 1 GNMT stearoyl-CoA desaturase-1 MTR SCD1 FGF21 S-adenosylhomocysteine Sirt1 AMPK ACC Gpd2 cystathionase TNFα LBP SAM MAT1A Betaine-homocysteine S-methyltransferase PGC1 8-Oxo-deoxyguanosine AMP-activated protein kinase PPARs ROS Ucp1 Atgl S-adenosylmethionine acetyl-CoA carboxylase Sulfur amino acids insulin-like growth factor-1 Adipose tissue White adipose tissue triglyceride Oxidative stress tumor necrosis factor-alpha Uncoupling protein-1 Insulin sensitivity Aging cystathionine β-synthase fibroblast growth factor 21 Fischer 344 adipose triglyceride lipase Lipid metabolism Methionine synthase Methionine restriction Protein restriction caloric restriction Growth hormone lipopolysaccharide binding protein adiposity WAT glycine N-methyltransferase Reactive oxygen species Peroxisome proliferator-activated receptors