| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10736934 | Experimental Gerontology | 2013 | 13 Pages |
Abstract
⺠Methionine restriction decreases mtROS production at complex I and mtDNA damage. ⺠Restriction of dietary protein can be the first (partial) DR-mimic for human beings. ⺠mtDNA is situated close to or even in contact with the site of mtROS generation. ⺠That disposition helps to control the longevity of the different animal species. ⺠A low rate of generation of endogenous damage is a main trait of long-lived animals.
Keywords
IGFinsulin/insulin-like growth factor signaling8-oxodGIISS-adenosylhomocysteineSAHBERnDNASAMMitochondrial DNANuclear DNADNA damagebase excision repairmtDNAAgingInsulin-like growth factorComplex Idietary restrictionMethionine restrictionProtein restrictionMitochondrial oxygen consumptionMitochondriaReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Ines Sanchez-Roman, Gustavo Barja,