Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10736943 | Experimental Gerontology | 2013 | 5 Pages |
Abstract
The morbidity of ocular diseases, including macular degeneration, diabetic retinopathy, and dry eye disease, has been gradually increasing worldwide. Because these diseases develop from age-associated ocular dysfunctions, interventions against the aging process itself may be a promising strategy for their management. Among the several approaches to interrupt aging processes, calorie restriction (CR) has been shown to recover and/or slow age-related functional declines in various organs, including the eye. Here, we review interventions against the aging process as potential therapeutic approaches to age-related ocular diseases. The effects of CR and CR mimetics in animal models of age-related eye diseases are explored. Furthermore, we discuss the possibilities of expanding this research to prospective studies to elucidate the molecular mechanisms by which CR and/or CR mimetics preserve ocular functions.
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Motoko Kawashima, Yoko Ozawa, Ken Shinmura, Takaaki Inaba, Shigeru Nakamura, Tetsuya Kawakita, Mitsuhiro Watanabe, Kazuo Tsubota,