Reserpine modulates neurotransmitter release to extend lifespan and alleviate age-dependent Aβ proteotoxicity in Caenorhabditis elegans

► Reserpine mediated lifespan extension(RMLE) requires neurotransmitter release modulation. ► Reserpine modulates presynaptic acetylcholine release to bring about RMLE. ► Reserpine's alleviation of Aβ toxicity is through modulation of acetylcholine release. ► Mineral ions negatively contribute to Aβ toxicity and their reduction enhances amelioration of Aβ toxicity.