Age and obesity-associated changes in the expression and activation of components of the AMPK signaling pathway in human right atrial tissue

► We evaluated AMPK signaling in RA tissue in normal weight/obese, young/old patients. ► Acrp30 is decreased in serum/epicardial fat-tissue in old and obese patients. ► AMPK activation was high in the RA of obese patients (young and old). ► LKB1 expression showed a strong positive correlation with AMPK activation. ► Phosphorylation of AMPK-targets mTOR, eEF-2 and ACC was not altered.