| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737019 | Experimental Gerontology | 2013 | 7 Pages |
Abstract
⺠First report on CAF, a neurotrypsin proteolysis product of agrin. ⺠Agrin proteolysis (CAF) is detectable in humans and elevated in sarcopenia patients. ⺠This report links elevated proteolysis of the neuromuscular junction to sarcopenia. ⺠Selective inhibition of neurotrypsin lowers agrin degradation.
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Authors
Stefan Hettwer, Pius Dahinden, Stefan Kucsera, Carlo Farina, Shaheen Ahmed, Ruggero Fariello, Michael Drey, Cornel Christian Sieber, Jan Willem Vrijbloed,