| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737033 | Experimental Gerontology | 2011 | 6 Pages |
Abstract
⺠JNK signaling is a conserved regulator of lifespan. ⺠Multiple physiological processes are controlled by JNK to influence lifespan. ⺠JNK promotes oxidative stress tolerance and regulates apoptosis. ⺠Antagonism between JNK and insulin signaling influences metabolic homeostasis and lifespan. ⺠Excessive JNK activity negatively influences lifespan by disrupting intestinal regeneration.
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Authors
Benoit Biteau, Jason Karpac, DaeSung Hwangbo, Heinrich Jasper,