| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737063 | Experimental Gerontology | 2011 | 8 Pages |
Abstract
⺠Aging muscle incurs greater damage following ischemia/reperfusion than in young. ⺠IGF-I expression in both peptide and mRNA of IGF-I were reduced in aging. ⺠Anabolic activity of aged muscle subsequent to injury was reduced compared to young. ⺠Aging reduced phosphorylation of intermediates of the PI3 Kinase pathway in muscle. ⺠Altered IGF-I signaling in aging muscle impairs recovery.
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Authors
David W. Hammers, Ronald W. Jr., Christian Sell, Martin L. Adamo, Thomas J. Walters, J. Scot Estep, Roger P. Farrar,