| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737064 | Experimental Gerontology | 2011 | 9 Pages |
Abstract
⺠Codrug 1 by reducing beta amyloid plaque formation. ⺠Codrug 1 by inhibiting NOS signalling pathway. ⺠Codrug 1 by counteracting apoptosis occurrence. ⺠Codrug 1 protects Alzheimer's diseased rat brain against memory impairment and behavioural detriment.
Keywords
APPRNSDABCOXRMENFTsNOSNGSNSAIDSROScyclooxygenaseAlzheimer's diseaseTUNELNon-steroidal anti-inflammatory drugsCNSRamBBBBlood–brain barriernormal goat serumNitric oxide synthasescentral nervous systemIbuprofenIbuRat brainneurofibrillary tanglesNitric oxidenitric oxide synthaseamyloid precursor proteinAmyloid plaquesreactive nitrogen speciesReactive oxygen species
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Authors
Susi Zara, Antonio Di Stefano, Cinzia Nasuti, Monica Rapino, Antonia Patruno, Mirko Pesce, Piera Sozio, Laura S. Cerasa, Amelia Cataldi,