| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738151 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠Transsulfuration-defective Cthâ/â mice displayed hepatitis upon excessive Met intake. ⺠Metabolome analysis revealed accumulation of Met oxidation/transamination products. ⺠Metabolome analysis revealed deficiency of Cys-derived antioxidants, GSH and taurine. ⺠Transsulfuration was found to be essential for effective clearance of overloaded Met.
Keywords
APTTALTTBARSGSSGSAMGSHCBSCThSAHDICMTPS-adenosylhomocysteineCE–MScystathionine γ-lyaseROSASTAspartate aminotransferaseAlanine aminotransferaseALPAlkaline phosphataseAntioxidantsS-adenosylmethioninecapillary electrophoresis–mass spectrometrydisseminated intravascular coagulationTransaminationTranssulfurationterminal deoxynucleotidyl transferase dUTP nick-end labelingTUNELBUNactivated partial thromboplastin timeprothrombin timecystathionine β-synthaseMethionine sulfoxidelactate dehydrogenaseLDHMatMetabolomemethionine adenosyltransferaseblood urea nitrogenhomocysteinereduced glutathioneCreatine kinaseliquid chromatographyoxidized glutathioneReactive oxygen species
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Authors
Hidenori Yamada, Noriyuki Akahoshi, Shotaro Kamata, Yoshifumi Hagiya, Takako Hishiki, Yoshiko Nagahata, Tomomi Matsuura, Naoharu Takano, Masatomo Mori, Yasuki Ishizaki, Takashi Izumi, Yoshito Kumagai, Tadashi Kasahara, Makoto Suematsu, Isao Ishii,