| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10747653 | Advances in Biological Regulation | 2013 | 7 Pages |
Abstract
In this manuscript, involvement of PLD in fMLP-induced superoxide generation and degranulation were re-investigated using PLDâ/â neutrophils, and the molecular mechanisms of these neutrophil functions were examined. Neither PLD1 nor PLD2 is involved in these fMLP-induced neutrophil functions. The results obtained in this study provide evidence that cPKC plays an important role in fMLP-induced superoxide generation. On the other hand, Ca2+-dependent signaling pathway and cPKC seem to be involved in degranulation.
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Authors
Yasunori Kanaho, Takanobu Sato, Tsunaki Hongu, Yuji Funakoshi,