| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10747903 | Biochemical and Biophysical Research Communications | 2016 | 7 Pages |
Abstract
Fatigue reduces productivity and is a risk factor for lifestyle diseases and mental disorders. Everyone experiences physiological fatigue and recovers with rest. Pathological fatigue, however, greatly reduces quality of life and requires therapeutic interventions. It is therefore necessary to distinguish between the two but there has been no biomarker for this. We report on the measurement of salivary human herpesvirus (HHV-) 6 and HHV-7 as biomarkers for quantifying physiological fatigue. They increased with military training and work and rapidly decreased with rest. Our results suggested that macrophage activation and differentiation were necessary for virus reactivation. However, HHV-6 and HHV-7 did not increase in obstructive sleep apnea syndrome (OSAS), chronic fatigue syndrome (CFS) and major depressive disorder (MDD), which are thought to cause pathological fatigue. Thus, HHV-6 and HHV-7 would be useful biomarkers for distinguishing between physiological and pathological fatigue. Our findings suggest a fundamentally new approach to evaluating fatigue and preventing fatigue-related diseases.
Keywords
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Authors
Ryo Aoki, Nobuyuki Kobayashi, Go Suzuki, Hirohiko Kuratsune, Kazuya Shimada, Naomi Oka, Mayumi Takahashi, Wataru Yamadera, Masayuki Iwashita, Shinichi Tokuno, Masashi Nibuya, Masaaki Tanichi, Yasuo Mukai, Keiji Mitani, Kazuhiro Kondo, Hiroshi Ito,