| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10747951 | Biochemical and Biophysical Research Communications | 2016 | 6 Pages |
Abstract
miR-199b-5p is up-regulated significantly during the osteogenesis process in human bone marrow stromal cells (BMSCs). Inhibiting miR-199b-5p notably reduces while over-expressing miR-199b-5p promotes the BMSCs osteoblast differentiation, suggested by the alternations of osteogenic genes expression, ALP activity and the ARS-stained mineral nodules. miR-199b-5p exerts its role in BMSC osteogenesis most probably through the GSK-3β/β-catenin signaling pathway. In conclusion, the present study revealed for the first time that miR-199b-5p plays a positive role in osteoblast differentiation.
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Authors
Ruibo Zhao, Yusheng Li, Zhangyuan Lin, Jun Wan, Can Xu, Yong Zeng, Yong Zhu,