| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10748105 | Biochemical and Biophysical Research Communications | 2016 | 30 Pages |
Abstract
A novel glycotoxin inhibitor, URM-II-81, modulated key molecules of proximal and distal insulin signaling and hence alleviated glycotoxin mediated diminished insulin signaling. URM-II-81 also increased glycogen synthesis and glucose uptake in liver and fat cells, respectively. Novel derivative of isatin showed significant reduced receptor for AGEs (RAGE) expression, antioxidant activity and PKC-alpha activation, therefore; URM-II-81 reduced glycotoxin induced insulin resistance.287
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Authors
Shabbir Khan Afridi, Meha Fatima Aftab, Munazza Murtaza, Safina Ghaffar, Aneela Karim, Uzma Rasool Mughal, Khalid Mohammed Khan, Rizwana Sanaullah Waraich,