Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10748337 | Biochemical and Biophysical Research Communications | 2016 | 6 Pages |
Abstract
In the present study, we constructed ZFP809 proteins containing mutated linkers and examined their ability to silence transgene expression driven by MLV, binding ability to MLV PBS, and cellular localization. The results of the present study revealed that the linkers affected the ability of ZFP809 to silence transgene expression. Furthermore, this effect could be partly attributed to changes in the localization of ZFP809 proteins containing mutated linkers. Further characterization of ZFP809 linkers is required for understanding the functions and features of KRAB-ZFP-containing linkers.
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Authors
Yu Ichida, Yuko Utsunomiya, Masafumi Onodera,