| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10748463 | Biochemical and Biophysical Research Communications | 2016 | 6 Pages |
Abstract
In conclusion, we identified PEK-1 as a mediator of hormesis in the mev-1 mutant of C. elegans which is induced by simultaneous inhibition of XBP-1 and its splicing activator IRE-1 and mediated through activation of the proteasome.
Keywords
ATF-6Suc-LLVY-AMCIRE-1ERADXBP-1UPRinositol requiring enzyme 1eIF2αBiPC. elegansER associated degradationRNA interferenceRNAiROSAbuanalysis of varianceANOVAUbiquitin-proteasome systemendoplasmic reticulumeukaryotic initiation factor 2αactivating transcription factor 6HormesisUnfolded protein responseProteasomeProteostasisX-box binding protein 1Immunoglobulin binding proteinprotein kinase RNA-like ER kinaseCaenorhabditis elegansReactive oxygen speciesUPS
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Authors
Dorothé Jenni Eisermann, Uwe Wenzel, Elena Fitzenberger,