| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10748896 | Biochemical and Biophysical Research Communications | 2016 | 6 Pages |
Abstract
Schematic model for glucose-stimulated SPP1 expression mediated by histone modifications. High glucose stimulates SPP1 gene expression via histone modification changes which involve increased H3K4me1, H3K4me3 and H3K9ac; as well as decreased H3K27me3 in the promoter region of SPP1. The basal SPP1 expression can be enhanced by inhibition of HDAC; while glucose-stimulated expression of SPP1 can be reversed by inhibition of HMT.115
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Authors
Mengyin Cai, Pradeep Bompada, David Atac, Markku Laakso, Leif Groop, Yang De Marinis,