| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10749006 | Biochemical and Biophysical Research Communications | 2016 | 6 Pages |
Abstract
KCNQ1/KCNE3 channels make only a small contribution to basolateral conductance in normal colonic crypts, with increased channel activity in UC appearing insufficient to prevent colonic cell depolarization in this disease. This supports the proposal that defective Na+ absorption rather than enhanced Clâ secretion, is the dominant pathophysiological mechanism of diarrhea in UC.
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Authors
Adel Al-Hazza, John Linley, Qadeer Aziz, Malcolm Hunter, Geoffrey Sandle,