Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10749200 | Biochemical and Biophysical Research Communications | 2015 | 8 Pages |
Abstract
Metabolic syndrome characterized by hyperglycemia contributes to nonalcoholic steatohepatitis-associated liver fibrosis. This study was to investigate the effects of Acid-sensing ion Channel 1a (ASIC1a) on the process of liver fibrosis under hyperglycemia. Results showed that high glucose significantly worsen the pathology of liver fibrosis in vivo. In vitro, high glucose stimulated proliferation, activation and extracellular matrix (ECM) production in HSCs, and enhanced the effect of PDGF-BB on the activation and proliferation of HSCs. These effects could be attenuated by ASIC1a specific inhibitor Psalmotoxin-1(PcTx1) or specific ShRNA for ASIC1a through Notch1/Hes-1 pathways. These data indicate that ASIC1a plays an important role in diabetes complication liver fibrosis.
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Authors
Huan Wang, Ying-hong Wang, Feng Yang, Xiao-feng Li, Yuan-yao Tian, Ming-ming Ni, Long-quan Zuo, Xiao-Ming Meng, Yan Huang,