Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10749252 | Biochemical and Biophysical Research Communications | 2015 | 27 Pages |
Abstract
Red wines are thought to be one of the major dietary sources of trans-resveratrol. The beneficial effects of t-resveratrol against metabolic disorders have been well characterized, however, red wines also contain various resveratrol derivatives whose health benefits have not been completely elucidated. In this report, we investigated ε-viniferin, a resveratrol dimer, which is present at comparable concentrations to t-resveratrol in red wines, and has higher anti-adipogenesis activity in 3T3-L1 cells. In addition, ε-viniferin was more effective than t-resveratrol in its anti-obesity and anti-inflammatory effects in high-fat diet fed mice. These results suggested ε-viniferin may be one of the active ingredients against metabolic disorders in red wines, in addition to t-resveratrol.
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Authors
Kazuaki Ohara, Kaori Kusano, Sayoko Kitao, Takaaki Yanai, Ryoji Takata, Osamu Kanauchi,