| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10749554 | Biochemical and Biophysical Research Communications | 2016 | 24 Pages |
Abstract
Absence of NLRP3 results in increased myocardial infarct size after in vivo ischemia reperfusion, seemingly due to dysfunction of the cardioprotective RISK pathway. Our data imply that NLRP3 contributes to cardio-protection during I/R and do not support a role for NLRP3 or ASC inhibition in the management of acute MI including revascularization therapy.
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Authors
Ã. Sandanger, E. Gao, T. Ranheim, M. Bliksøen, O.J. Kaasbøll, K. Alfsnes, StÃ¥le H. Nymo, A. Rashidi, I.K. Ohm, HÃ¥vard Attramadal, P. Aukrust, L.E. Vinge, A. Yndestad,