Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10749585 | Biochemical and Biophysical Research Communications | 2016 | 7 Pages |
Abstract
We found that SLC25A43 knockdown in MCF10A cells significantly inhibited cell cycle progression during G1-to-S transition, thus significantly reducing the proliferation rate and fraction of Ki-67 positive MCF10A cells. In contrast, suppressed SLC25A43 expression in BT-474Â cells resulted in a significantly increased proliferation rate together with an enhanced G1-to-S transition. This was reflected by an increased fraction of Ki-67 positive cells and reduced level of nuclear p21. In line with our previous results, we show a role for SLC25A43 as a regulator of cell cycle progression and proliferation through a putative mitochondrial checkpoint. These novel data further strengthen the connection between mitochondrial function and the cell cycle, both in non-malignant and in cancer cells.
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Authors
Marike Gabrielson, Edwin Reizer, Olle Stål, Elisabet Tina,