Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10750315 | Biochemical and Biophysical Research Communications | 2015 | 9 Pages |
Abstract
In conclusion, less BH4 and reduced NO increases myocardial hypertrophy and cardiac oxidative stress, which exacerbates diastolic dysfunction. Exogenous BH4 ameliorates cardiac hypertrophy and diastolic dysfunction through the PI3K/p-Akt pathway. BH4 may be a potent therapy for hypertension with diastolic dysfunction.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Peng Chang, Qiongying Wang, Han Xu, Mina Yang, Xin Lin, Xiuli Li, Zhengyi Zhang, Xiaowei Zhang, Feng Zhao, Xu Zhao, Feng Bai, Jing Yu,