Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10750322 | Biochemical and Biophysical Research Communications | 2016 | 7 Pages |
Abstract
Recently, targeting deregulated energy metabolism is an emerging strategy for cancer therapy. In the present study, combination of DCA and metformin markedly induced cell death, compared with each drug alone. Furthermore, the expression levels of glycolytic enzymes including HK2, LDHA and ENO1 were downregulated by two drugs. Interestingly, HIF-1α activation markedly suppressed DCA/metformin-induced cell death and recovered the expressions of glycolytic enzymes that were decreased by two drugs. Based on these findings, we propose that targeting HIF-1α is necessary for cancer metabolism targeted therapy.
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Authors
Sung-Eun Hong, Hyeon-Ok Jin, Hyun-Ah Kim, Min-Ki Seong, Eun-Kyu Kim, Sang-Kyu Ye, Tae-Boo Choe, Jin Kyung Lee, Jong-Il Kim, In-Chul Park, Woo Chul Noh,