Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10750569 | Biochemical and Biophysical Research Communications | 2015 | 7 Pages |
Abstract
Although miR-564 was reported to be dysregulated in human malignancy, the function and mechanism of miR-564 in tumorigenesis remains unknown. In the present study, we found that miR-564 frequently downregulated in lung cancer cells and significantly inhibited cell proliferation, cell cycle progression, motility, and the tumorigenicity of lung cancer cells. Moreover, we identified zic family member 3 (ZIC3) as a direct target of miR-564. ZIC3 overexpression impaired the suppressive effects of miR-564 on the capacity of lung cancer cells for proliferation and motility. Finally, we detected the expression level of miR-564 and ZIC3 protein in tissue specimens, and found a significant negative correlation between them. Patients with low levels of miR-564 showed a poorer overall survival. Taken together, our present study revealed the tumor suppressor role of miR-564, indicating restoration of miR-564 as a potential therapeutic strategy for the treatment of lung cancer.
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Authors
Bin Yang, Lin Jia, Qiaojuan Guo, Hui Ren, Desheng Hu, Xiaoyi Zhou, Qingrong Ren, Yanping Hu, Tao Xie,